NIH Guidelines for Research Involving Recombinant DNA Molecules
Welcome to the UNC-CH NIH Guidelines for Research Involving Recombinant DNA Molecules training course. The course provides information in order for the principal investigator to make sure that his/her laboratory is in compliance with the National Institute of Health Guidelines for such research. In addition, the Guidelines identify key ethical principles and key safety reporting requirements, applicable to all researchers who work with recombinant DNA molecules. Once the module has been completed, click on the post test and complete to receive credit for the training. If you have any questions regarding this training or any safety issue, please call (919) 962-5507.
Modules: click on Course Overview to begin or use the links below to navigate to specific sections.
| Course Overview |
| Introduction |
| Course Overview |
| Course Overview, con't |
| Course Overview, con't |
| Learning Aids |
| Program Modules |
| Introduction to the Guidelines |
| Introduction to the NIH Guidelines |
| NIH Office of Biotechnology Activities |
| History of the Guidelines Development |
| Scope of the Guidelines |
| Scope of the Guidelines |
| Definition: Recombinant DNA Molecules |
| Definition: Recombinant DNA Molecules, con't |
| Definition: siRNA |
| Definition: Transgenic Animals |
| Example: Cre/loxP System |
| The NIH Guidelines are Applicable To: |
| Non-Compliance Consequences |
| Knowledge Review |
| Roles and Responsibilities |
| Roles and Responsibilities |
| Roles and Responsibilities, con't |
| Roles and Responsibilities of: |
| Institutional (UNC's) Responsibilities |
| Institutional Biosafety Committee (IBC) Responsibilities |
| Environment, Health and Safety Responsibilities |
| Principal Investigator Responsibilities |
| Principal Investigator Responsibilities, con't |
| Principal Investigator Responsibilities, con't |
| Principal Investigator's Responsibilities for Human Use Protocols |
| Principal Investigator's Responsibilities for Human Use Protocols, con't. |
| NIH Responsibilities |
| Please Review the Following Instructions Before Proceeding to the Next Module |
| Knowledge Review |
| Choose Your Job Type |
| Experiments Covered |
| Experiments Covered |
| Experiments Covered by the NIH Guidelines |
| rDNA Decision Matrix |
| Next Step for the PI |
| Knowledge Review |
| Safety Issues |
| Risk Assessment |
| Principal Investigator's Risk Assessment |
| Principal Investigator's Risk Assessment, con't |
| Risk Groups |
| Risk Group 1 |
| Risk Group 1, con't |
| Risk Group 2 |
| Risk Group 3 |
| Risk Group 4 |
| Knowledge Review |
| Submission to IBC |
| Submission to IBC and IBC Review |
| Submission of rDNA Registrations to IBC |
| Oversight |
| Animal Use Experiments |
| IBC and IACUC Review of Animal Research Utilizing Recombinant DNA |
| Human Use Experiments |
| IBC and IRB Review of Research with Human Subjects |
| Procedures: Submission of rDNA Registrations to IBC |
| Procedures, con't.: Submission of rDNA Registrations to IBC |
| Knowledge Review |
| Incident Reporting |
| Incident Reporting |
| Requirements for Reporting |
| Incident Definition |
| Incident Procedures |
| How to Report Incidents |
| How to Report Incidents, con't. |
| Additonal Information in the NIH Guidelines: Appendices |
| Additonal Information in the NIH Guidelines: Appendices, con't. |
| Knowledge Review |
| Post Test |
| rDNA Test |
| Test Time |
Test Requirements: remember that you must take and pass the post test in order to receive credit for this training. Choose your post test:
- If you do not work with recombinant DNA or transgenic animals/plants, please click here to take your post-test.
- If you do work with recombinant DNA or transgenic animals or plants, please click here to take your post-test.
Environment, Health & Safety | 1120 Estes Drive Extension, CB#1650 | Chapel Hill, NC 27599
Phone 919-962-5507 | Fax 919-962-0227 |
Department Email Contact
