To: All UNC Principal Investigators
From: Pete Reinhardt, Director of Environment, Health & Safety
Date: October 21, 2003
Re: Department of Commerce Shipping Licenses

This memo is to inform you of license requirements for certain international shipments of infectious agents and toxins. Shipments out of the United States of any agent or toxin, listed with the Department of Commerce, or genetic elements from any of these agents, requires a license from the Department of Commerce.

The pathogens and toxins requiring a Department of Commerce license are listed below. Organisms on the list are regulated even if it is a vaccine strain. USDA and FDA vaccines approved for clinical trials do not require a license. Investigational new drugs in their final trials may not need a license.

If you ship any of the listed agents, pleaseĀ contact staff for assistance in obtaining these permits. It can take up to eight weeks to obtain a license.

Human and Zoonotic Pathogens and Toxins

Chikungunya virus; Congo-Crimean haemorrhagic fever virus; Dengue fever virus; Eastern equine encephalitis virus; Ebola virus; Hantaan virus; Japanese encephalitis virus; Junin virus; Lassa fever virus; Lymphocytic choriomeningitis virus; Machupo virus; Marburg virus; Monkey pox virus; Rift Valley fever virus; Tick-borne encephalitis virus (Russin Spring-Summer encephalitis virus); Variola virus; Venezuelan equine encephalitis virus; Western equine encephalitis virus; White pox; or Yellow fever virus.
Bartonella quintana (Rochalimea quintana, Rickettsia quintana); Coxiella burnetii; Rickettsia prowasecki; or Rickettsia rickettsii.
Bacillus anthracis; Brucella abortus; Brucella melitensis; Brucella suis; Burkholderia mallei (Pseudomonas mallei); Burkholderia pseudomallei (Pseudomonas psudomallei); Chlamydia psittaci; Clostridium botulinum; Francisella tularensis; Salmonella typhi; Shigella dysenteriae; Vibrio cholerae; Yersinia pestis. “Toxins”, as follows, and “subunits” thereof: Botulinum toxins; Clostridium perfringens toxins; Conotoxin; Microcystin (Cyanginosin); Ricin.
Saxitoxin; Shiga toxin; Staphylococcus aureus toxins; Tetrodotoxin; Verotoxin; Aflatoxins; Abrin; Cholera toxin; Diacetoxyscirpenol toxin; T-2 toxin; HT-2 toxin; Modeccin toxin; Volkensin toxin; or Viscum Album Lectin 1 (Viscumin).

Animal Pathogens

African swine fever virus; Avian influenza virus that are: Type A viruses with an IVPI (intravenous pathogenicity index) in 6 week old chickens of greater than 1.2; or Type A viruses H5 or H7 subtype for which nucleotide sequencing has demonstrated multiple basic amino acids at the cleavage site of haemagglutinin; Bluetongue virus; Foot and mouth disease virus; Goat pox virus; Porcine herpes virus (Aujeszky’s disease); Swine fever virus (Hog cholera virus); Lyssa virus; Newcastle disease virus; Peste des petits ruminants virus; Porcine enterovirus type 9 (swine vesicular disease virus); Rinderpest virus; Sheep pox virus; Teschen disease virus; Vesicular stomatitis virus.
Mycoplasma mycoides.
Plant Pathogens
Bacteria Xanthomonas albilineans; Xanthomonas campestris pv. citri including strains referred to as Xanthomonas campestris pv. citri types A, B, C, D, E or otherwise classified as Xanthomonas citri, Xanthomonas campestris pv. aurantifolia or Xanthomonas campestris pv. citrumelo.
Collectotrichum coffeanum var. virulans (Colletotrichum kahawae); Cochliobolus miyaveanus (Helminthosporium oryzae); Microcyclus ulei (syn. Dothidella ulei); Puccinia graminis (syn. Puccinia graminis f. sp. tritici); Puccinia striiformis (syn. Puccinia glumarum); Magnaporthe grisea (pyricularia grisea/pyricularia).