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The following items require approval by the Department of Environment, Health and Safety prior to purchase or acquisition. Please call 919-962-5507 to request approval.

  • Select COI
  • Polio Virus
  • Biological Safety Cabinets
  • Chemical Fume (Exhaust) Hoods
  • Controlled Substances
  • Toxic Gases
  • Ductless Fume Hoods
  • Select Agents (see below)

Radioactive materials or x-ray machines cannot be purchased or acquired without the approval of the UNC Radiation Safety Officer. Please call 919-962-5507 for approval.

Please notify the UNC Laser Safety Officer (919-962-5507) if you purchase or acquire a class 3b or 4 laser.

Agents That Require EHS Approval

View the list at or below.

HHS Select Agents and Toxins

  • Abrin
  • Botulinum neurotoxins*
  • Botulinum neurotoxin producing species of Clostridium*
  • Conotoxins (Short, paralytic alpha conotoxins containing the following amino acid sequence X1CCX2PACGX3X4X5X6CX7)
  • Coxiella burnetii
  • Crimean-Congo haemorrhagic fever virus
  • Diacetoxyscirpenol
  • Eastern Equine Encephalitis virus1
  • Ebola virus*
  • Francisella tularensis*
  • Lassa fever virus
  • Lujo virus
  • Marburg virus*
  • Monkeypox virus1
  • Reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments (Reconstructed 1918 Influenza virus)
  • Ricin
  • Rickettsia prowazekii
  • SARS-associated coronavirus (SARS-CoV)
  • Saxitoxin
  • South American Haemorrhagic Fever viruses:
    • Chapare
    • Guanarito
    • Junin
    • Machupo
    • Sabia
  • Staphylococcal enterotoxins A,B,C,D,E subtypes
  • T-2 toxin
  • Tetrodotoxin
  • Tick-borne encephalitis complex (flavi) viruses:
    • Far Eastern subtype
    • Siberian subtype
  • Kyasanur Forest disease virus
  • Omsk hemorrhagic fever virus
  • Variola major virus (Smallpox virus)*
  • Variola minor virus (Alastrim)*
  • Yersinia pestis*

Overlap Select Agents and Toxins

  • Bacillus anthracis*
  • Bacillus anthracis Pasteur strain
  • Brucella abortus
  • Brucella melitensis
  • Brucella suis
  • Burkholderia mallei*
  • Burkholderia pseudomallei*
  • Hendra virus
  • Nipah virus
  • Rift Valley fever virus
  • Venezuelan equine encephalitis virus1

USDA Select Agents and Toxins

  • African horse sickness virus
  • African swine fever virus
  • Avian influenza virus1
  • Classical swine fever virus
  • Foot-and-mouth disease virus*
  • Goat pox virus
  • Lumpy skin disease virus
  • Mycoplasma capricolum1
  • Mycoplasma mycoides1
  • Newcastle disease virus1,2
  • Peste des petits ruminants virus
  • Rinderpest virus*
  • Sheep pox virus
  • Swine vesicular disease virus

USDA Plant Protection and Quarantine (PPQ) Select Agents and Toxins

  • Peronosclerospora philippinensis (Peronosclerospora sacchari)
  • Phoma glycinicola (formerly Pyrenochaeta glycines)
  • Ralstonia solanacearum
  • Rathayibacter toxicus
  • Sclerophthora rayssiae
  • Synchytrium endobioticum
  • Xanthomonas oryzae

*Denotes Tier 1 Agent

1 Select agents that meet any of the following criteria are excluded from the requirements of this part: Any low pathogenic strains of avian influenza virus, South American genotype of eastern equine encephalitis virus , west African clade of Monkeypox viruses, any strain of Newcastle disease virus which does not meet the criteria for virulent Newcastle disease virus, all subspecies Mycoplasma capricolum except subspecies capripneumoniae (contagious caprine pleuropneumonia), all subspecies Mycoplasma mycoides except subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia), any subtypes of Venezuelan equine encephalitis virus except for Subtypes IAB or IC, and Vesicular stomatitis virus (exotic): Indiana subtypes VSV-IN2, VSV-IN3, provided that the individual or entity can verify that the agent is within the exclusion category.

2 A virulent Newcastle disease virus (avian paramyxovirus serotype 1) has an intracerebral pathogenicity index in day-old chicks (Gallus gallus) of 0.7 or greater or has an amino acid sequence at the fusion (F) protein cleavage site that is consistent with virulent strains of Newcastle disease virus. A failure to detect a cleavage site that is consistent with virulent strains does not confirm the absence of a virulent virus.